Editorial policy on genome-scale analyses

Editorial policy

Section 1, Neurobiolo~, will accept manuscripts on a broad range of experimental approaches which aim to understand the neuronal mechanisms that underlie vision. Relevant ideas include physiological optics, phototransduction, neurotransmitters, functional anatomy, electrophysiology, development and regeneration. The Editors seek submissions concerning structure and function at all levels of vis...

Editorial Policy

Editorial policy

Section 1, Neurobiology, will accept manuscripts on a broad range of experimental approaches which aim to understand the neuronal mechanisms that underlie vision. Relevant ideas include physiological optics, phototransduction, neurotransmitters, functional anatomy, electrophysiology, development and regeneration. The Editors seek submissions concerning structure and function at all levels of vi...

Ancient large-scale genome duplications: phylogenetic and linkage analyses shed light on chordate genome evolution.

Paralogous genes from several families were found in four human chromosome regions (4p16, 5q33-35, 8p12-21, and 10q24-26), suggesting that their common ancestral region underwent several rounds of large-scale duplication. Searches in the EMBL databases, followed by phylogenetic analyses, showed that cognates (orthologs) of human duplicated genes can be found in other vertebrates, including bony...

Editorial: Updated guidance on human genome epidemiology (HuGE) reviews and meta-analyses of genetic associations.

Even before the human genome was sequenced, Khoury and Dorman published an editorial in the American Journal of Epidemiology (AJE) calling for a population-based approach to health-related discoveries that stemmed from the Human Genome Project (1). The approach was termed “human genome epidemiology” (HuGE for short) and led to the formation of an informal collaboration (HuGENet) (2) to explore ...